Listar CIBA - Artículos por título

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A Novel MSH6 Gene Variant in a Lynch Syndrome Patient with Lipomas

Giannoni, Ana Paula; Sevic, Ina; Parenti, Fernanda; Alaniz, Laura (2023-04-07)

Colorectal cancer is one of the most frequently occurring cancers today, with a large percentage of cases having a hereditary basis. Lynch syndrome is the most common cause of hereditary colorectal cancer. The genetic ...
Altered interferon-γ expression in lymphocytes as a potential peripheral marker of chronic stress-induced cognitive deficit

Palumbo, María Laura; Di Rosso, María Emilia; Simon, Elias Hugo; Gonzalez Murano, María Rosa; Genaro, Ana María (Elsevier, 2018-07)

It is known that long-term exposure to stressful situations can produce severe consequences affecting behavioral, endocrine and immunological parameters. We have previously shown that stressed BALB/c mice had poor learning ...
Co-treatment of tumor cells with hyaluronan plus doxorubicin affects endothelial cell behavior independently of VEGF expression

Vitale, Daiana Luján; Spinelli, Fiorella Mercedes; Del Dago, Daiana; Icardi, Antonella; Demarchi, Gianina; Caon, Ilaria; García, Mariana; Bolontrade, Marcela; Passi, Alberto; Cristina, Carolina; Alaniz, Laura (2018-11-27)

Hyaluronan, the main glycosaminoglycan of extracellular matrices, is concentrated in tissues with high cell proliferation and migration rates. In cancer, hyaluronan expression is altered and it becomes fragmented into ...
Epidemiology of Clostridioides difficile Infection in Argentina and Associated Risk Factors Evaluated Through a Meta-Analysis

Barbero, Angela María; Moriconi, Nicolás Diego; Palma, Sabina; Celano, Josefina; Balbi, María Gracia; Morro, Lorenzo Sebastián; Calvo Zarlenga, María Martina; Suárez, Jorgelina; Martínez, María Guadalupe; Machain, Mónica Graciela; Altamiranda, Carlos Gabriel; Erbiti, Gabriel; Hernández Del Pino, Rodrigo Emanuel; Pasquinelli, Virginia (MDPI (Multidisciplinary Digital Publishing Institute), 2026-05-22)

Introducción: Clostridioides difficile está clasificada entre las 18 principales amenazas de resistencia a los antimicrobianos y es la causa principal de infección entérica nosocomial. Los casos asociados a la comunidad ...
Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1

Barbero, Angela María; Hernández Del Pino, Rodrigo Emanuel; García, Verónica Edith; Pasquinelli, Virginia (Journal of Visualized Experiments, 2025-02-28)

La evaluación de la interacción directa entre patógenos y receptores inmunitarios suele implicar técnicas sofisticadas o el uso de cepas transgénicas y células modificadas genéticamente. En este trabajo, se describe un ...
Hyaluronan Metabolism is Associated with DNA Repair Genes in Breast and Colorectal Cancer

Sevic, Ina; Spinelli, Fiorella Mercedes; Vitale, Daiana Luján; Icardi, Antonella; Romano, Lucia; Brandone, Alejandra; Giannoni, Paula; Cristina, Carolina; Bolontrade, Marcela Fabiana; Alaniz, Laura (MDPI, 2020-06-29)

In this work, we compared mRNA levels of Hyaluronan (HA) metabolism members and BRCA genes, known to be involved in the tumoral process, between tumor and non-tumor adjacent tissue and its correlation with previously ...
Hyaluronan preconditioning of monocytes/macrophages affects their angiogenic behavior and regulation of TSG-6 expression in a tumor type-specific manner

Spinelli, Fiorella Mercedes; Vitale, Daiana Luján; Icardi, Antonella; Caon, Ilaria; Brandone, Alejandra; Giannoni, Paula; Saturno, Virginia; Passi, Alberto; García, Mariana; Sevic, Ina; Alaniz, Laura (2019-04-29)

Hyaluronan is a glycosaminoglycan normally present in the extracellular matrix in most tissues. Hyaluronan is a crucial player in many processes associated with cancer, such as angiogenesis, invasion, and metastasis. ...
Inhibition of Notch signaling attenuates pituitary adenoma growth in Nude mice

Zubeldía-Brenner, Lautaro; De Winne, Catalina; Perrone, Sofía; Rodríguez-Seguí, Santiago A; Willems, Christophe; Ornstein, Ana María; Lacau-Mengido, Isabel; Vankelecom, Hugo; Cristina, Carolina; Becu-Villalobos, Damasia (Bioscientifica, 2018-08-18)

Preclinical and clinical studies support that Notch signaling may play an important oncogenic role in cancer, but there is scarce information for pituitary tumors. We therefore undertook a functional study to evaluate Notch ...
Initial Identification of UDP-Glucose Dehydrogenase as a Prognostic Marker in Breast Cancer Patients, Which Facilitates Epirubicin Resistance and Regulates Hyaluronan Synthesis in MDA-MB-231 Cells

Vitale, Daiana Luján; Caon, Ilaria; Parnigoni, Arianna; Sevic, Ina; Spinelli, Fiorella Mercedes; Icardi, Antonella; Passi, Alberto; Vigetti, Davide; Alaniz, Laura (2021-02-09)

UDP-glucose-dehydrogenase (UGDH) synthesizes UDP-glucuronic acid. It is involved in epirubicin detoxification and hyaluronan synthesis. This work aimed to evaluate the effect of UGDH knockdown on epirubicin response and ...
Platelets promote human macrophages-mediated macropinocytosis of Clostridioides difficile

Barbero, Angela María; Hernández Del Pino, Rodrigo Emanuel; Fuentes, Federico; Barrionuevo, Paula; Pasquinelli, Virginia (2024-01-05)

Clostridioides difficile es el principal agente causal de diarreas hospitalarias. La infección por C. difficile (CDI) es una enfermedad potencialmente letal, cuya terapia actual es el uso de antibióticos sin ser totalmente ...
Proteoglycans and glycosaminoglycans as regulators of cancer stem cell function and therapeutic resistance

Vitale, Daiana Luján; Katakam, Sampath Kumar; Greve, Burkhard; Jang, Bohee; Oh, Eok-Soo; Alaniz, Laura; Gotte, Martin (2019-06-19)

In contrast to the bulk of the tumor, a subset of cancer cells called cancer stem cells (CSC; or tumor-initiating cells) is characterized by self-renewal, unlimited proliferative potential, expression of multidrug ...
Targeting the Tumor Extracellular Matrix by the Natural Molecule 4-Methylumbelliferone: A Complementary and Alternative Cancer Therapeutic Strategy

Vitale, Daiana Luján; Icardi, Antonella; Rosales, Paolo; Spinelli, Fiorella Mercedes; Sevic, Ina; Alaniz, Laura (2021-10-04)

In antineoplastic therapy, one of the challenges is to adjust the treatment to the needs of each patient and reduce the toxicity caused by conventional antitumor strategies. It has been demonstrated that natural products ...
The effects of sulfated hyaluronan in breast, lung and colorectal carcinoma and monocytes/macrophages cells: Its role in angiogenesis and tumor progression

Spinelli, Fiorella Mercedes; Rosales, Paolo; Pluda, Stefano; Vitale, Daiana Luján; Icardi, Antonella; Guarise, Cristian; Reszegi, Andrea; Kovalszky, Ilona; García, Mariana; Sevic, Ina; Galesso, Devis; Alaniz, Laura (2022-01-31)

Hyaluronan (HA) is a component of the extracellular matrix (ECM) it is the main non-sulfated glycosaminoglycan able to modulate cell behavior in the healthy and tumor context. Sulfated hyaluronan (sHA) is a biomaterial ...
The immunological effect of hyaluronan in tumor angiogenesis

Spinelli, Fiorella M; Vitale, Daiana L; Demarchi, Gianina; Cristina, Carolina; Alaniz, Laura (Wiley-Blackwell, 2015-12-04)

The relationship between the immune system and angiogenesis has been described in several contexts, both in physiological and pathological conditions, as pregnancy and cancer. In fact, different types of immune cells, such ...
The Notch system during pubertal development of the bovine mammary gland

Bonadeo, Nadia; Becu-Villalobos, Damasia; Cristina, Carolina; Lacau-Mengido, Isabel M. (Nature Research, 2019-06-20)

The development of the mammary gland of cows during pre-weaning and puberty will condition its future productive capacity and warrants special study. In this respect, Notch signaling regulates tissue development and fate ...