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CIBA - Artículos
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El Centro de Investigaciones Básicas y Aplicadas (CIBA) de la UNNOBA, es un centro multidisciplinario de investigación cuyo objetivo es impulsar el desarrollo tecnológico y la generación de conocimiento en las áreas de ciencias de la medicina aplicada, así como también las ciencias del ambiente. El cumplimiento de dichos objetivos se consigue a través de la investigación, formación de recursos humanos, prestación de servicios a terceros, y establecimiento de acuerdos con la comunidad científica, académica, médica y empresarial, estrechando vínculos con instituciones locales, nacionales e internacionales.
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(2023-04-07)Colorectal cancer is one of the most frequently occurring cancers today, with a large percentage of cases having a hereditary basis. Lynch syndrome is the most common cause of hereditary colorectal cancer. The genetic ...
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(2021-02-09)UDP-glucose-dehydrogenase (UGDH) synthesizes UDP-glucuronic acid. It is involved in epirubicin detoxification and hyaluronan synthesis. This work aimed to evaluate the effect of UGDH knockdown on epirubicin response and ...
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(2018-11-27)Hyaluronan, the main glycosaminoglycan of extracellular matrices, is concentrated in tissues with high cell proliferation and migration rates. In cancer, hyaluronan expression is altered and it becomes fragmented into ...
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(2022-01-31)Hyaluronan (HA) is a component of the extracellular matrix (ECM) it is the main non-sulfated glycosaminoglycan able to modulate cell behavior in the healthy and tumor context. Sulfated hyaluronan (sHA) is a biomaterial ...
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(2019-06-19)In contrast to the bulk of the tumor, a subset of cancer cells called cancer stem cells (CSC; or tumor-initiating cells) is characterized by self-renewal, unlimited proliferative potential, expression of multidrug ...
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(2021-10-04)In antineoplastic therapy, one of the challenges is to adjust the treatment to the needs of each patient and reduce the toxicity caused by conventional antitumor strategies. It has been demonstrated that natural products ...
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(2019-04-29)Hyaluronan is a glycosaminoglycan normally present in the extracellular matrix in most tissues. Hyaluronan is a crucial player in many processes associated with cancer, such as angiogenesis, invasion, and metastasis. ...
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(Nature Research, 2019-06-20)The development of the mammary gland of cows during pre-weaning and puberty will condition its future productive capacity and warrants special study. In this respect, Notch signaling regulates tissue development and fate ...
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(Bioscientifica, 2018-08-18)Preclinical and clinical studies support that Notch signaling may play an important oncogenic role in cancer, but there is scarce information for pituitary tumors. We therefore undertook a functional study to evaluate Notch ...
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(Wiley-Blackwell, 2015-12-04)The relationship between the immune system and angiogenesis has been described in several contexts, both in physiological and pathological conditions, as pregnancy and cancer. In fact, different types of immune cells, such ...
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(MDPI, 2020-06-29)In this work, we compared mRNA levels of Hyaluronan (HA) metabolism members and BRCA genes, known to be involved in the tumoral process, between tumor and non-tumor adjacent tissue and its correlation with previously ...
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(Elsevier, 2018-07)It is known that long-term exposure to stressful situations can produce severe consequences affecting behavioral, endocrine and immunological parameters. We have previously shown that stressed BALB/c mice had poor learning ...