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dc.rights.license | https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ | es_ES |
dc.creator | Vitale, Daiana Luján | es_ES |
dc.creator | Caon, Ilaria | es_ES |
dc.creator | Parnigoni, Arianna | es_ES |
dc.creator | Sevic, Ina | es_ES |
dc.creator | Spinelli, Fiorella Mercedes | es_ES |
dc.creator | Icardi, Antonella | es_ES |
dc.creator | Passi, Alberto | es_ES |
dc.creator | Vigetti, Davide | es_ES |
dc.creator | Alaniz, Laura | es_ES |
dc.date.accessioned | 2023-12-04T20:05:51Z | |
dc.date.available | 2023-12-04T20:05:51Z | |
dc.date.issued | 2021-02-09 | |
dc.identifier.citation | Vitale D. L., Caon I., Parnigoni A., Sevic I., Spinelli F. M., Icardi A., Passi A., Vigetti D., Alaniz L. (2021). Initial Identification of UDP-Glucose Dehydrogenase as a Prognostic Marker in Breast Cancer Patients, Which Facilitates Epirubicin Resistance and Regulates Hyaluronan Synthesis in MDA-MB-231 Cells. Biomolecules, 11(2), 246 | es_ES |
dc.identifier.issn | 2218-273X | es_ES |
dc.identifier.uri | http://repositorio.unnoba.edu.ar/xmlui/handle/23601/637 | |
dc.description.abstract | UDP-glucose-dehydrogenase (UGDH) synthesizes UDP-glucuronic acid. It is involved in epirubicin detoxification and hyaluronan synthesis. This work aimed to evaluate the effect of UGDH knockdown on epirubicin response and hyaluronan metabolism in MDA-MB-231 breast cancer cells. Additionally, the aim was to determine UGDH as a possible prognosis marker in breast cancer. We studied UGDH expression in tumors and adjacent tissue from breast cancer patients. The prognostic value of UGDH was studied using a public Kaplan–Meier plotter. MDA-MB-231 cells were knocked-down for UGDH and treated with epirubicin. Epirubicin-accumulation and apoptosis were analyzed by flow cytometry. Hyaluronan-coated matrix and metabolism were determined. Autophagic-LC3-II was studied by Western blot and confocal microscopy. Epirubicin accumulation increased and apoptosis decreased during UGDH knockdown. Hyaluronan-coated matrix increased and a positive modulation of autophagy was detected. Higher levels of UGDH were correlated with worse prognosis in triple-negative breast cancer patients that received chemotherapy. High expression of UGDH was found in tumoral tissue from HER2--patients. However, UGDH knockdown contributes to epirubicin resistance, which might be associated with increases in the expression, deposition and catabolism of hyaluronan. The results obtained allowed us to propose UGDH as a new prognostic marker in breast cancer, positively associated with development of epirubicin resistance and modulation of extracellular matrix. | es_ES |
dc.description.sponsorship | Fil: Vitale, Daiana Luján. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones Básicas y Aplicadas. Laboratorio de Microambiente Tumoral; Argentina | es_ES |
dc.description.sponsorship | Fil: Vitale, Daiana Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. CIT NOBA (UNNOBA-UNSADA-CONICET); Argentina | es_ES |
dc.description.sponsorship | Fil: Caon, Ilaria. Università degli Studio dell’Insubria. Dipartimento di Medicina e Chirurgia; Italia | es_ES |
dc.description.sponsorship | Fil: Parnigoni, Arianna. Università degli Studio dell’Insubria. Dipartimento di Medicina e Chirurgia; Italia | es_ES |
dc.description.sponsorship | Fil: Sevic, Ina. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones Básicas y Aplicadas. Laboratorio de Microambiente Tumoral; Argentina | es_ES |
dc.description.sponsorship | Fil: Sevic, Ina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina | es_ES |
dc.description.sponsorship | Fil: Spinelli, Fiorella Mercedes. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones Básicas y Aplicadas. Laboratorio de Microambiente Tumoral; Argentina | es_ES |
dc.description.sponsorship | Fil: Spinelli, Fiorella Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina | es_ES |
dc.description.sponsorship | Fil: Icardi, Antonella. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones Básicas y Aplicadas. Laboratorio de Microambiente Tumoral; Argentina | es_ES |
dc.description.sponsorship | Fil: Icardi, Antonella. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina | es_ES |
dc.description.sponsorship | Fil: Passi, Alberto. Università degli Studio dell’Insubria. Dipartimento di Medicina e Chirurgia; Italia | es_ES |
dc.description.sponsorship | Fil: Vigetti, Davide. Università degli Studio dell’Insubria. Dipartimento di Medicina e Chirurgia; Italia | es_ES |
dc.description.sponsorship | Fil: Alaniz, Laura. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones Básicas y Aplicadas. Laboratorio de Microambiente Tumoral; Argentina | es_ES |
dc.description.sponsorship | Fil: Alaniz, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina | es_ES |
dc.format | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.relation | eu-repo/grantAgreement/European Comission/H2020 RISE-MSCA Project/645,756/GLYCANC | es_ES |
dc.relation | eu-repo/grantAgreement/UNNOBA/SIB 2019/0561-2019 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.source | Biomolecules | es_ES |
dc.subject | UDP-glucose dehydrogenase | es_ES |
dc.subject | Hyaluronan | es_ES |
dc.subject | Epirubicin | es_ES |
dc.subject | Drug resistance | es_ES |
dc.subject | Extracellular matrix | es_ES |
dc.subject | Breast cancer | es_ES |
dc.title | Initial Identification of UDP-Glucose Dehydrogenase as a Prognostic Marker in Breast Cancer Patients, Which Facilitates Epirubicin Resistance and Regulates Hyaluronan Synthesis in MDA-MB-231 Cells | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.type | info:ar-repo/semantics/artículo | es_ES |
dc.type | info:eu-repo/semantics/publishedVersion | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.type | info:ar-repo/semantics/artículo | es_ES |
dc.type | info:eu-repo/semantics/publishedVersion | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.type | info:ar-repo/semantics/artículo | es_ES |
dc.type | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.version | Con referato | es_ES |
dc.relation.publisherversion | https://doi.org/10.3390/biom11020246 | es_ES |
dc.contributor.orcid | 0000-0001-5593-9101 | es_ES |
dc.contributor.orcid | 0000-0003-3328-3089 | es_ES |
dc.contributor.orcid | 0000-0002-6070-6078 | es_ES |