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dc.rights.license | https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ | es_ES |
dc.creator | Spinelli, Fiorella Mercedes | es_ES |
dc.creator | Rosales, Paolo | es_ES |
dc.creator | Pluda, Stefano | es_ES |
dc.creator | Vitale, Daiana Luján | es_ES |
dc.creator | Icardi, Antonella | es_ES |
dc.creator | Guarise, Cristian | es_ES |
dc.creator | Reszegi, Andrea | es_ES |
dc.creator | Kovalszky, Ilona | es_ES |
dc.creator | García, Mariana | es_ES |
dc.creator | Sevic, Ina | es_ES |
dc.creator | Galesso, Devis | es_ES |
dc.creator | Alaniz, Laura | es_ES |
dc.date.accessioned | 2023-12-04T19:33:26Z | |
dc.date.available | 2023-12-04T19:33:26Z | |
dc.date.issued | 2022-01-31 | |
dc.identifier.citation | Spinelli F. M., Rosales P., Pluda S., Vitale D. L., Icardi A., Guarise C., Reszegi A., Kovalszky I., García M., Sevic I., Galesso D., Alaniz L. (2022). The effects of sulfated hyaluronan in breast, lung and colorectal carcinoma and monocytes/macrophages cells: Its role in angiogenesis and tumor progression. IUBMB Life, 74(10), 927-942. | es_ES |
dc.identifier.issn | 1521-6551 | es_ES |
dc.identifier.uri | http://repositorio.unnoba.edu.ar/xmlui/handle/23601/635 | |
dc.description.abstract | Hyaluronan (HA) is a component of the extracellular matrix (ECM) it is the main non-sulfated glycosaminoglycan able to modulate cell behavior in the healthy and tumor context. Sulfated hyaluronan (sHA) is a biomaterial derived from chemical modifications of HA, since this molecule is not naturally sulfated. The HA sulfation modifies several properties of the native molecule, acquiring antitumor properties in different cancers. In this study, we evaluated the action of sHA of 30–60 kDa with different degrees of sulfation (0.7 sHA1 and 2.5 sHA3) on tumor cells of a breast, lung, and colorectal cancer model and its action on other cells of the tumor microenvironment, such as endothelial and monocytes/macrophage cells. Our data showed that in breast and lung tumor cells, sHA3 is able to modulate cell viability, cytotoxicity, and proliferation, but no effects were observed on colorectal cancer cells. In 3D cultures of breast and lung cancer cells, sHA3 diminished the size of the tumorsphere and modulated total HA levels. In these tumor models, treatment of monocytes/ macrophages with sHA3 showed a downregulation of the expression of angiogenic factors. We also observed a decrease in endothelial cell migration and modulation of the hyaluronan-binding protein TSG-6. In the breast in vivo xenograft model, monocytes/macrophages preincubated with sHA1 or sHA3 decreased tumor vasculature, TSG-6 and HA levels. Besides, in silico analysis showed an association of TSG-6, HAS2, and IL-8 with biological processes implicated in the progression of the tumor. Taken together, our data indicate that sHA in a breast and lung tumor context is able to induce an antiangiogenic action on tumor cells as well as in onocytes/macrophages (Mo/MØ) by modulation of endothelial migration, angiogenic factors, and vessel formation. | es_ES |
dc.description.sponsorship | Fil: Spinelli, Fiorella Mercedes. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones Básicas y Aplicadas. Laboratorio de Microambiente Tumoral; Argentina | es_ES |
dc.description.sponsorship | Fil: Spinelli, Fiorella Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina | es_ES |
dc.description.sponsorship | Fil: Rosales, Paolo. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones Básicas y Aplicadas. Laboratorio de Microambiente Tumoral; Argentina | es_ES |
dc.description.sponsorship | Fil: Rosales, Paolo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina | es_ES |
dc.description.sponsorship | Fil: Pluda, Stefano. Fidia Farmaceutici S.p.A.; Italia | es_ES |
dc.description.sponsorship | Fil: Vitale, Daiana Luján. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones Básicas y Aplicadas. Laboratorio de Microambiente Tumoral; Argentina | es_ES |
dc.description.sponsorship | Fil: Vitale, Daiana Luján. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina | es_ES |
dc.description.sponsorship | Fil: Icardi, Antonella. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones Básicas y Aplicadas. Laboratorio de Microambiente Tumoral; Argentina | es_ES |
dc.description.sponsorship | Fil: Icardi, Antonella. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina | es_ES |
dc.description.sponsorship | Fil: Guarise, Cristian. Fidia Farmaceutici S.p.A.; Italia | es_ES |
dc.description.sponsorship | Fil: Reszegi, Andrea. Semmelweis University. Department of Pathology and Experimental Cancer Research; Hungría | es_ES |
dc.description.sponsorship | Fil: Kovalszky, Ilona. Semmelweis University. Department of Pathology and Experimental Cancer Research; Hungría | es_ES |
dc.description.sponsorship | Fil: García, Mariana. Universidad Austral. IIMT–CONICET. Laboratorio de Terapia Génica; Argentina | es_ES |
dc.description.sponsorship | Fil: Sevic, Ina. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones Básicas y Aplicadas. Laboratorio de Microambiente Tumoral; Argentina | es_ES |
dc.description.sponsorship | Fil: Sevic, Ina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina | es_ES |
dc.description.sponsorship | Fil: Galesso, Devis. Fidia Farmaceutici S.p.A.; Italia | es_ES |
dc.description.sponsorship | Fil: Alaniz, Laura. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones Básicas y Aplicadas. Laboratorio de Microambiente Tumoral; Argentina | es_ES |
dc.description.sponsorship | Fil: Alaniz, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina | es_ES |
dc.format | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.relation | eu-repo/grantAgreement/European Comission/H2020 RISE-MSCA Project/645,756/GLYCANC | es_ES |
dc.relation | eu-repo/grantAgreement/UNNOBA/SIB 2019/0561-2019 | es_ES |
dc.relation | eu-repo/grantAgreement/Fundación Roemmers 2018 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.source | IUBMB Life | es_ES |
dc.subject | Angiogenesis | es_ES |
dc.subject | Monocytes/macrophages | es_ES |
dc.subject | Sulfated hyaluronan | es_ES |
dc.subject | Tumor microenvironment | es_ES |
dc.title | The effects of sulfated hyaluronan in breast, lung and colorectal carcinoma and monocytes/macrophages cells: Its role in angiogenesis and tumor progression | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.type | info:ar-repo/semantics/artículo | es_ES |
dc.type | info:eu-repo/semantics/publishedVersion | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.type | info:ar-repo/semantics/artículo | es_ES |
dc.type | info:eu-repo/semantics/publishedVersion | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.type | info:ar-repo/semantics/artículo | es_ES |
dc.type | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.version | Con referato | es_ES |
dc.relation.publisherversion | doi: 10.1002/iub.2604 | es_ES |
dc.contributor.orcid | 0000-0001-5593-9101 | es_ES |
dc.contributor.orcid | 0000-0002-6070-6078 | es_ES |