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dc.rights.license | https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ | es_ES |
dc.creator | Spinelli, Fiorella Mercedes | es_ES |
dc.creator | Vitale, Daiana Luján | es_ES |
dc.creator | Icardi, Antonella | es_ES |
dc.creator | Caon, Ilaria | es_ES |
dc.creator | Brandone, Alejandra | es_ES |
dc.creator | Giannoni, Paula | es_ES |
dc.creator | Saturno, Virginia | es_ES |
dc.creator | Passi, Alberto | es_ES |
dc.creator | García, Mariana | es_ES |
dc.creator | Sevic, Ina | es_ES |
dc.creator | Alaniz, Laura | es_ES |
dc.date.accessioned | 2023-12-04T18:38:40Z | |
dc.date.available | 2023-12-04T18:38:40Z | |
dc.date.issued | 2019-04-29 | |
dc.identifier.citation | Spinelli F.M., Vitale D.L., Icardi A., Caon I., Brandone A., Giannoni P., Saturno V., Passi A., García M., Sevic I., Alaniz L. (2019). Hyaluronan preconditioning of monocytes/macrophages affects their angiogenic behavior and regulation of TSG-6 expression in a tumor type-specific manner. The FEBS Journal, 286(17), 3433-3449. | es_ES |
dc.identifier.issn | 1742-4658 | es_ES |
dc.identifier.uri | http://repositorio.unnoba.edu.ar/xmlui/handle/23601/632 | |
dc.description.abstract | Hyaluronan is a glycosaminoglycan normally present in the extracellular matrix in most tissues. Hyaluronan is a crucial player in many processes associated with cancer, such as angiogenesis, invasion, and metastasis. However, little has been reported regarding the action of hyaluronan on monocytes/ macrophages (Mo/MØ) in tumor angiogenesis and its consequences on tumor development. In the present study, we investigated the effects of hyaluronan of different sizes on human Mo/MØ angiogenic behavior in colorectal and breast carcinoma. In vitro, the treatment of Mo/MØ with lysates and conditioned media from a breast but not from colorectal carcinoma cell line plus high-molecular weight hyaluronan induced: (a) an increased expression of angiogenic factors VEGF, IL-8, FGF-2, and MMP-2, (b) an increased endothelial cell migration, and (c) a differential expression of hyaluronan-binding protein TSG-6. Similar results were observed in Mo/ MØ derived from breast cancer patients treated with tumor lysates. Besides, macrophages primed with high-molecular weight hyaluronan and inoculated in human breast cancer xenograft tumor increased blood vessel formation and diminished TSG-6 levels. In contrast, the effects triggered by highmolecular weight hyaluronan on Mo/MØ in breast cancer context were not observed in the context of colorectal carcinoma. Taken together, these results indicate that the effect of high-molecular weight hyaluronan as an inductor of the angiogenic behavior of macrophages in breast tumor context is in part consequence of the presence of TSG-6. | es_ES |
dc.description.sponsorship | Fil: Spinelli, Fiorella Mercedes. Universidad Nacional del Noroeste de la Provincia de Buenos Aires (UNNOBA). Centro de Investigaciones Básicas y Aplicadas (CIBA). Laboratorio de Microambiente Tumoral; Argentina | es_ES |
dc.description.sponsorship | Fil: Spinelli, Fiorella Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina | es_ES |
dc.description.sponsorship | Fil: Vitale, Daiana Luján. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones Básicas y Aplicadas. Laboratorio de Microambiente Tumoral; Argentina | es_ES |
dc.description.sponsorship | Fil: Vitale, Daiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina | es_ES |
dc.description.sponsorship | Fil: Icardi, Antonella. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones Básicas y Aplicadas. Laboratorio de Microambiente Tumoral; Argentina | es_ES |
dc.description.sponsorship | Fil: Icardi, Antonella. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina | es_ES |
dc.description.sponsorship | Fil: Caon, Ilaria. Università degli Studio dell’Insubria. Dipartimento di Medicina e Chirurgia; Italia | es_ES |
dc.description.sponsorship | Fil: Brandone, Alejandra. Hospital Interzonal General de Agudos Dr. Abraham F. Piñeyro; Argentina | es_ES |
dc.description.sponsorship | Fil: Giannoni, Paula. Clínica Centro; Argentina | es_ES |
dc.description.sponsorship | Fil: Saturno, Virginia. Hospital Interzonal General de Agudos Dr. Abraham F. Piñeyro; Argentina | es_ES |
dc.description.sponsorship | Fil: Passi, Alberto. Università degli Studio dell’Insubria. Dipartimento di Medicina e Chirurgia; Italia | es_ES |
dc.description.sponsorship | Fil: García, Mariana. Universidad Austral. IIMT–CONICET. Laboratorio de Terapia Génica; Argentina | es_ES |
dc.description.sponsorship | Fil: Sevic, Ina. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones Básicas y Aplicadas. Laboratorio de Microambiente Tumoral; Argentina | es_ES |
dc.description.sponsorship | Fil: Sevic, Ina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina | es_ES |
dc.description.sponsorship | Fil: Alaniz, Laura. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones Básicas y Aplicadas. Laboratorio de Microambiente Tumoral; Argentina | es_ES |
dc.description.sponsorship | Fil: Alaniz, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina | es_ES |
dc.format | application/pdf | es_ES |
dc.language.iso | eng | es_ES |
dc.relation | eu-repo/grantAgreement/Ministerio de Salud/Instituto Nacional del Cáncer/PIO 2015/ID31-2015 | es_ES |
dc.relation | eu-repo/grantAgreement/European Comission/H2020 RISE-MSCA Project/645,756/GLYCANC | es_ES |
dc.relation | eu-repo/grantAgreement/UNNOBA/SIB 2017/01117-2017 | es_ES |
dc.relation | eu-repo/grantAgreement/Fundación Roemmers 2018 | es_ES |
dc.rights | info:eu-repo/semantics/openAccess | es_ES |
dc.source | The FEBS Journal | es_ES |
dc.subject | Angiogenesis | es_ES |
dc.subject | Breast carcinoma | es_ES |
dc.subject | Colorectal carcinoma | es_ES |
dc.subject | Hyaluronan | es_ES |
dc.subject | Monocytes/macrophages | es_ES |
dc.subject | TSG-6 | es_ES |
dc.title | Hyaluronan preconditioning of monocytes/macrophages affects their angiogenic behavior and regulation of TSG-6 expression in a tumor type-specific manner | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.type | info:ar-repo/semantics/artículo | es_ES |
dc.type | info:eu-repo/semantics/publishedVersion | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.type | info:ar-repo/semantics/artículo | es_ES |
dc.type | info:eu-repo/semantics/publishedVersion | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.type | info:ar-repo/semantics/artículo | es_ES |
dc.type | info:eu-repo/semantics/publishedVersion | es_ES |
dc.description.version | Con referato | es_ES |
dc.relation.publisherversion | doi:10.1111/febs.14871 | es_ES |
dc.contributor.orcid | 0000-0001-5593-9101 | es_ES |
dc.contributor.orcid | 0000-0003-3328-3089 | es_ES |
dc.contributor.orcid | 0000-0002-6070-6078 | es_ES |