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| dc.rights.license | https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ | es_ES |
| dc.creator | Sevic, Ina | es_ES |
| dc.creator | Spinelli, Fiorella Mercedes | es_ES |
| dc.creator | Vitale, Daiana Luján | es_ES |
| dc.creator | Icardi, Antonella | es_ES |
| dc.creator | Romano, Lucia | es_ES |
| dc.creator | Brandone, Alejandra | es_ES |
| dc.creator | Giannone, Paula | es_ES |
| dc.creator | Cristina, Carolina | es_ES |
| dc.creator | Bolontrade, Marcela Fabiana | es_ES |
| dc.creator | Alaniz, Laura | es_ES |
| dc.date.accessioned | 2020-09-25T15:43:16Z | |
| dc.date.available | 2020-09-25T15:43:16Z | |
| dc.date.issued | 2020-06-29 | |
| dc.identifier.citation | Sevic, I., Spinelli, F. M., Vitale, D. L., Icardi, A., Romano, L., Brandone, A., Giannone, P., Cristina, C., Bolontrade, M. F., & Alaniz, L. (2020). Hyaluronan Metabolism is Associated with DNA Repair Genes in Breast and Colorectal Cancer. Biomedicines. http://repositorio.unnoba.edu.ar:8080/xmlui/handle/23601/109 | es_ES |
| dc.identifier.issn | 2227-9059 | es_ES |
| dc.identifier.uri | http://repositorio.unnoba.edu.ar:8080/xmlui/handle/23601/109 | |
| dc.description.abstract | In this work, we compared mRNA levels of Hyaluronan (HA) metabolism members and BRCA genes, known to be involved in the tumoral process, between tumor and non-tumor adjacent tissue and its correlation with previously proposed biomarkers (ER, PR, HER2 and KI67) in order to assess their value as a progression biomarkers. We show alteration in HA metabolism in colorectal but not breast cancer. However, we found a decrease in Hyaluronidase 1 HYAL1 levels in the breast but not colorectal cancer. We also show lower HA levels in tumor compared with normal tissue that could indicate a possible influence of tumor on its surrounding "normal" tissue. In both breast and colorectal cancer, CD44 and BRCA2 showed a strong positive correlation. Besides, our results show first indicators that qPCR of the analyzed genes could be used as an easy and low cost procedure for the evaluation of molecular markers we propose here | es_ES |
| dc.description.sponsorship | Fil: Ina, Sevic. Universidad Nacional del Noroeste de la Pcia. de Bs. As (UNNOBA) , CIT NOBA (UNNOBA-UNSADA-CONICET), Centro de Investigaciones Básicas y Aplicadas (CIBA), Laboratorio de Microambiente Tumoral. Junin, Bs. As. Argentina | es_ES |
| dc.description.sponsorship | Fil: Spinelli, Fiorella Mercedes. Universidad Nacional del Noroeste de la Pcia. de Bs. As (UNNOBA) , CIT NOBA (UNNOBA-UNSADA-CONICET), Centro de Investigaciones Básicas y Aplicadas (CIBA), Laboratorio de Microambiente Tumoral. Junin, Bs. As. Argentina | es_ES |
| dc.description.sponsorship | Fil: Vitale, Daiana Lujan. Universidad Nacional del Noroeste de la Pcia. de Bs. As (UNNOBA) , CIT NOBA (UNNOBA-UNSADA-CONICET), Centro de Investigaciones Básicas y Aplicadas (CIBA), Laboratorio de Microambiente Tumoral. Junin, Bs. As. Argentina | es_ES |
| dc.description.sponsorship | Fil: Icardi, Antonella. Universidad Nacional del Noroeste de la Pcia. de Bs. As (UNNOBA) , CIT NOBA (UNNOBA-UNSADA-CONICET), Centro de Investigaciones Básicas y Aplicadas (CIBA), Laboratorio de Microambiente Tumoral. Junin, Bs. As. Argentina | es_ES |
| dc.description.sponsorship | Fil: Brandone, Alejandra, Hospital Interzonal General de Agudos Dr. Abraham F. Piñeyro, Junín, Bs. As. Argentina | es_ES |
| dc.description.sponsorship | Fil: Giannone, Paula. Clínica Centro. Junín Bs. As, Argentina | es_ES |
| dc.description.sponsorship | Fil: Romano, Lucia. CIT NOBA (UNNOBA-UNSADA-CONICET), Centro de Investigaciones Básicas y Aplicadas (CIBA), Junin, Bs. As. Argentina | es_ES |
| dc.description.sponsorship | Fil: Cristina, Carolina. Universidad Nacional del Noroeste de la Pcia. de Bs. As (UNNOBA) , CIT NOBA (UNNOBA-UNSADA-CONICET), Centro de Investigaciones Básicas y Aplicadas (CIBA). Laboratorio de Fisiopatología de la Hipófisis. Junin, Bs. As. Argentina | es_ES |
| dc.description.sponsorship | Fil: Bolontrade, Marcela Fabiana. Hospital Italiano. Instituto Universitario del Hospital Italiano-Instituto de Medicina Traslacional e Ingeniería Biomédica (IMTIB)-CONICET-Hospital Italiano. Buenos Aires (HIBA). CABA. Argentina | es_ES |
| dc.description.sponsorship | Fil: Alaniz, Laura. Universidad Nacional del Noroeste de la Pcia. de Bs. As (UNNOBA). CIT NOBA (UNNOBA-UNSADA-CONICET). Centro de Investigaciones Básicas y Aplicadas (CIBA). Laboratorio de Microambiente Tumoral; Junin, Bs. As. Argentina. | es_ES |
| dc.format | application/pdf | es_ES |
| dc.language.iso | eng | es_ES |
| dc.publisher | MDPI | es_ES |
| dc.relation | info:eu-repo/grantAgreement/ Fundación ROEMMERS, Subsidio para Investigación Médica 2017 | es_ES |
| dc.relation | info:eu-repo/grantAgreement/UNNOBA/SIB/2019-0561 | es_ES |
| dc.rights | info:eu-repo/semantics/closedAccess | es_ES |
| dc.source | Biomedicines | es_ES |
| dc.subject | Tumor microenvironment | es_ES |
| dc.subject | Hyaluronan | es_ES |
| dc.subject | Hyaluronan metabolism | es_ES |
| dc.subject | Breast cancer | es_ES |
| dc.subject | Colorectal cancer | es_ES |
| dc.subject | qPCR | es_ES |
| dc.title | Hyaluronan Metabolism is Associated with DNA Repair Genes in Breast and Colorectal Cancer. | es_ES |
| dc.title | Screening of Potential Progression Markers Using qPCR | es_ES |
| dc.type | info:eu-repo/semantics/article | es_ES |
| dc.type | info:ar-repo/semantics/artículo | es_ES |
| dc.type | info:eu-repo/semantics/draft | es_ES |
| dc.type | info:eu-repo/semantics/article | es_ES |
| dc.type | info:ar-repo/semantics/artículo | es_ES |
| dc.type | info:eu-repo/semantics/draft | es_ES |
| dc.type | info:eu-repo/semantics/article | es_ES |
| dc.type | info:ar-repo/semantics/artículo | es_ES |
| dc.type | info:eu-repo/semantics/draft | es_ES |
| dc.description.version | Con referato | es_ES |
| dc.relation.publisherversion | https://doi.org/10.3390/biomedicines8070183 | es_ES |
| dc.contributor.orcid | https://orcid.org/0000-0002-6070-6078 | es_ES |
| dc.contributor.orcid | https://orcid.org/0000-0002-4920-5096 | es_ES |
| dc.contributor.orcid | https://orcid.org/0000-0002-8664-5541 | es_ES |
| dc.contributor.orcid | https://orcid.org/0000-0001-8451-7055 | es_ES |
| dc.contributor.orcid | https://orcid.org/0000-0001-5593-9101 | es_ES |
| dc.contributor.orcid | https://orcid.org/0000-0003-0459-6721 | es_ES |
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CIBA - Artículos [12]
Centro de Investigaciones básicas y aplicadas