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Browsing by Author "0000-0001-5593-9101"

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Co-treatment of tumor cells with hyaluronan plus doxorubicin affects endothelial cell behavior independently of VEGF expression

Vitale, Daiana Luján; Spinelli, Fiorella Mercedes; Del Dago, Daiana; Icardi, Antonella; Dermarchi, Gianina; Caon, Ilaria; García, Mariana; Bolontrade, Marcela; Passi, Alberto; Cristina, Carolina; Alaniz, Laura (2018-11-27)

Hyaluronan, the main glycosaminoglycan of extracellular matrices, is concentrated in tissues with high cell proliferation and migration rates. In cancer, hyaluronan expression is altered and it becomes fragmented into ...
Hyaluronan preconditioning of monocytes/macrophages affects their angiogenic behavior and regulation of TSG-6 expression in a tumor type-specific manner

Spinelli, Fiorella Mercedes; Vitale, Daiana Luján; Icardi, Antonella; Caon, Ilaria; Brandone, Alejandra; Giannoni, Paula; Saturno, Virginia; Passi, Alberto; García, Mariana; Sevic, Ina; Alaniz, Laura (2019-04-29)

Hyaluronan is a glycosaminoglycan normally present in the extracellular matrix in most tissues. Hyaluronan is a crucial player in many processes associated with cancer, such as angiogenesis, invasion, and metastasis. ...
Initial Identification of UDP-Glucose Dehydrogenase as a Prognostic Marker in Breast Cancer Patients, Which Facilitates Epirubicin Resistance and Regulates Hyaluronan Synthesis in MDA-MB-231 Cells

Vitale, Daiana Luján; Caon, Ilaria; Parnigoni, Arianna; Sevic, Ina; Spinelli, Fiorella Mercedes; Icardi, Antonella; Passi, Alberto; Vigetti, Davide; Alaniz, Laura (2021-02-09)

UDP-glucose-dehydrogenase (UGDH) synthesizes UDP-glucuronic acid. It is involved in epirubicin detoxification and hyaluronan synthesis. This work aimed to evaluate the effect of UGDH knockdown on epirubicin response and ...
Proteoglycans and glycosaminoglycans as regulators of cancer stem cell function and therapeutic resistance

Vitale, Daiana Luján; Katakam, Sampath Kumar; Greve, Burkhard; Jang, Bohee; Oh, Eok-Soo; Alaniz, Laura; Gotte, Martin (2019-06-19)

In contrast to the bulk of the tumor, a subset of cancer cells called cancer stem cells (CSC; or tumor-initiating cells) is characterized by self-renewal, unlimited proliferative potential, expression of multidrug ...
Targeting the Tumor Extracellular Matrix by the Natural Molecule 4-Methylumbelliferone: A Complementary and Alternative Cancer Therapeutic Strategy

Vitale, Daiana Luján; Icardi, Antonella; Rosales, Paolo; Spinelli, Fiorella Mercedes; Sevic, Ina; Alaniz, Laura (2021-10-04)

In antineoplastic therapy, one of the challenges is to adjust the treatment to the needs of each patient and reduce the toxicity caused by conventional antitumor strategies. It has been demonstrated that natural products ...
The effects of sulfated hyaluronan in breast, lung and colorectal carcinoma and monocytes/macrophages cells: Its role in angiogenesis and tumor progression

Spinelli, Fiorella Mercedes; Rosales, Paolo; Pluda, Stefano; Vitale, Daiana Luján; Icardi, Antonella; Guarise, Cristian; Reszegi, Andrea; Kovalszky, Ilona; García, Mariana; Sevic, Ina; Galesso, Devis; Alaniz, Laura (2022-01-31)

Hyaluronan (HA) is a component of the extracellular matrix (ECM) it is the main non-sulfated glycosaminoglycan able to modulate cell behavior in the healthy and tumor context. Sulfated hyaluronan (sHA) is a biomaterial ...

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Browsing by Author "0000-0001-5593-9101"

Browsing by Author "0000-0001-5593-9101"

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